Article

Somatic mutations reveal hyperactive Notch signaling and racial disparities in prurigo nodularis

2023-09-26

Abstract excerpt

Prurigo nodularis (PN) is a chronic inflammatory skin disease that disproportionately affects African Americans and is characterized by pruritic skin nodules of unknown etiology. Little is known about genetic alterations in PN pathogenesis, especially relating to somatic events which are often implicated in inflammatory conditions. We thus performed whole-exome sequencing on 54 lesional and nonlesional skin biopsi...

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Literature Corpus work: 121598a4-9618-53c5-a8b7-99a5fcd8948d
DOI: 10.1101/2023.09.25.23295810

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