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Comprehensive Transcriptomic Profiling of Nonatopic Prurigo Nodularis in Korean Patients Reveals Il-22-driven Epidermal Stress and Neuro-immuno-fibrotic Remodelling.

Acta dermato-venereologica - 18 May 2026

Kim Hei Sung, Kim Yoon-Seob, Yosipovitch Gil

Abstract excerpt

Prurigo nodularis (PN) is a chronic pruritic dermatosis with incompletely defined pathogenesis, and molecular data from East Asian populations are limited. We characterized the transcriptomic signatures of non-atopic PN in Korean patients to identify pathways linked to chronic itch and lesion persistence. RNA sequencing was performed on lesional and non-lesional skin from 17 PN patients and normal skin from 11...

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Source

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Identifiers

PMID: 42153310
DOI: 10.2340/actadv.v106.adv-2025-0169
PMCID: PMC13184443

Genes

CDKN1A
CXCL8
HRNR
IL4R
JAK1
JAK3
KRT16
KRT17
KRT6C
PLAUR
S100A7
SERPINB4
SOCS1
TRPV3
WNT5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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