Article

Puf4 Mediates Post-transcriptional Regulation of Caspofungin Resistance in <i>Cryptococcus neoformans</i>

2020-02-12

Abstract excerpt

Echinocandins have been on the market for 20 years, yet they are the newest class of antifungal drugs. The human fungal pathogen Cryptococcus neoformans is intrinsically resistant to the echinocandin antifungal drug caspofungin, which targets the β -1,3-glucan synthase encoded by the FKS1 . Analysis of a C. neoformans puf4 Δ mutant, lacking the pumilio/FBF RNA binding protein family member Puf4, revealed exace...

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Literature Corpus work: e34bfe79-5163-5132-8efe-c4448a2730c4
DOI: 10.1101/2020.02.10.943191

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