Article
Puf4 regulates both splicing and decay of HXL1 mRNA encoding the unfolded protein response transcription factor in Cryptococcus neoformans.
Eukaryotic cell - 1 Apr 2015
Glazier Virginia E, Kaur Jan Naseer, Brown Nancy T, Rivera Ashley A, Panepinto John C
Abstract excerpt
The endoplasmic reticulum (ER) responds to errors in protein folding or processing by induction of the unfolded protein response (UPR). During conditions of ER stress, unconventional splicing of an mRNA encoding the UPR-responsive transcription factor occurs at the ER surface, resulting in activation of the UPR. UPR activation is necessary for adaptation to ER stress and for the pathogenic fungus Cryptococcus...
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