Article

<i>In utero</i> estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

2019-08-30

Abstract excerpt

In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to carcinogenic transformation are unknown. Several lines of evidence indicate the stroma mediates endocrine disruption following early-life (or in utero) exposure. Herein, we utilized BPA as a model of estrogeni...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3460939-70b9-5034-8a13-b342f8b905c9
DOI: 10.1101/749044

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In utero</i> estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffnessDOI 10.1101/749044Read

In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffnessSemantic proximity Read

An <i>in utero</i> exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glandsSemantic proximity Read

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT stateSemantic proximity Read

Fibrous stroma: Driver and passenger in cancer developmentSemantic proximity Read

Collagen architecture in pregnancy-induced protection from breast cancerSemantic proximity Read

Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signalingSemantic proximity Read

The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor ProgressionSemantic proximity Read

Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A.Semantic proximity Read

Chronic exposure of mice to phthalates enhances TGF beta signaling and promotes uterine fibrosisSemantic proximity Read

Long-term dietary exposure to a mixture of phthalates enhances estrogen and beta-catenin signaling pathways, leading to endometrial hyperplasia in miceSemantic proximity Read

Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic DisordersSemantic proximity Read

Varying Susceptibility of the Female Mammary Gland to In Utero Windows of BPA Exposure.Semantic proximity Read