Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling

19 Oct 2023

Abstract excerpt

Tissue development entails genetically programmed differentiation of immature cell types to mature, fully differentiated cells. Exposure during development to non-mutagenic environmental factors can contribute to cancer risk, but the underlying mechanisms are not understood. We used a mouse model of endometrial adenocarcinoma that results from brief developmental exposure to an estrogenic chemical,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Estrogen and related hormone effects
Share to Reproductive System and Pregnancy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37856394
DOI: 10.1371/journal.pbio.3002334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signalingPMID 37856394Read ↗

Endocrine disruption of early uterine differentiation causes adenocarcinoma mediated by Wnt/β-catenin- and PI3K/AKT signalingSemantic proximity Read ↗

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT stateSemantic proximity Read ↗

Diethylstilbestrol exposure in utero: A paradigm for mechanisms leading to adult diseaseSemantic proximity Read ↗

Epigenomic reprogramming of the developing reproductive tract and disease susceptibility in adulthoodSemantic proximity Read ↗

SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical ExposureSemantic proximity Read ↗

Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in lifeSemantic proximity Read ↗

Environmental Exposure, DNA Methylation, and Gene RegulationSemantic proximity Read ↗

Epigenetic Modulation of Inflammatory Pathways in Myometrial Stem Cells and Risk of Uterine FibroidsSemantic proximity Read ↗

Uterine organoids reveal insights into epithelial specification and plasticity in development and diseaseSemantic proximity Read ↗

Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesisSemantic proximity Read ↗

Developmental diethylstilbestrol exposure alters genetic pathways of uterine cytodifferentiation.Semantic proximity Read ↗

Endocrine-disrupting chemicals (EDCs) and epigenetic regulation in embryonic development: Mechanisms, impacts, and emerging trendsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.