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Article

In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness

5 May 2020

Abstract excerpt

BACKGROUND: In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term molecular changes that predispose mammary cells to carcinogenic transformation are unknown. Herein, we investigated how endocrine disrupting compounds (EDCs) drive changes within the stroma that can contribute to breast cancer susceptibility....

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PMID: 32370801
DOI: 10.1186/s13058-020-01275-w

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