Article

Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic Disorders

2018-05-31

Abstract excerpt

The health impacts of endocrine disrupting chemicals (EDCs) remain debated and their tissue and molecular targets are poorly understood. Here, we leveraged systems biology approaches to assess the target tissues, molecular pathways, and gene regulatory networks associated with prenatal exposure to the model EDC Bisphenol A (BPA). Prenatal BPA exposure led to scores of transcriptomic and methylomic alterations in t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75c6054b-7b6b-517e-aa27-54920b72fbdf
DOI: 10.1101/336214

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic DisordersDOI 10.1101/336214Read

Multiomics Data Analyses Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic TraitsSemantic proximity Read

Developmental programming: Transcriptional regulation of visceral and subcutaneous adipose by prenatal bisphenol-A in female sheepSemantic proximity Read

Use of high-resolution metabolomics to assess the biological perturbations associated with maternal exposure to Bisphenol A and Bisphenol F among pregnant African American womenSemantic proximity Read

Placental-brain axis in females detected within broadly impacted metabolic gene networks protects against prenatal PCB exposureSemantic proximity Read

The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity.Semantic proximity Read

Bisphenol A-associated alterations in genome-wide DNA methylation and gene expression patterns reveal sequence-dependent and non-monotonic effects in human fetal liverSemantic proximity Read

ToxiTaRGET: a multi-omics resource for toxicant-responsive molecular targetsSemantic proximity Read

Cross-tissue molecular responses in the liver and blood after toxicant exposuresSemantic proximity Read

Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A.Semantic proximity Read

A mixture of endocrine disrupting chemicals linked to lower birth weight induces adipogenesis and transcriptional changes related to birth weight alterations and diabetesSemantic proximity Read

Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 MiceSemantic proximity Read

Multi-omics architecture of childhood obesity and metabolic dysfunction uncovers biological pathways and prenatal determinantsSemantic proximity Read