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Article

Collagen architecture in pregnancy-induced protection from breast cancer

1 Jan 2013

Abstract excerpt

The reduction in breast cancer risk attributed to early-age pregnancy is mediated in part by changes in the mammary epithelium. Here, we address the role of the mammary stroma in this protection. Utilizing tumor cells capable of transitioning from indolent to proliferative or invasive states, we demonstrate that mammary extracellular matrix (ECM) from parous rats (parous matrix) decreases tumor growth and impedes...

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PMID: 23843613
DOI: 10.1242/jcs.121590

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