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Fibrous stroma: Driver and passenger in cancer development

8 Mar 2022

Abstract excerpt

Cumulative evidence shows that fibrogenic stroma and stiff extracellular matrix (ECM) not only result from tumor growth but also play pivotal roles in cellular transformation and tumor initiation. This emerging concept may largely account for the increased cancer risk associated with environmental fibrogenic agents, such as asbestos and silica, and with chronic conditions that are fibrogenic, such as obesity and...

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PMID: 35258999
DOI: 10.1126/scisignal.abg3449

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