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Article

An evolutionarily conserved innate immunity protein interaction network.

The Journal of biological chemistry - 18 Jan 2013

De Arras Lesly, Seng Amara, Lackford Brad, Keikhaee Mohammad R, Bowerman Bruce, Freedman Jonathan H, Schwartz David A, Alper Scott

Abstract excerpt

The innate immune response plays a critical role in fighting infection; however, innate immunity also can affect the pathogenesis of a variety of diseases, including sepsis, asthma, cancer, and atherosclerosis. To identify novel regulators of innate immunity, we performed comparative genomics RNA interference screens in the nematode Caenorhabditis elegans and mouse macrophages. These screens have uncovered many...

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Source

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Identifiers

PMID: 23209288
DOI: 10.1074/jbc.M112.407205
PMCID: PMC3548504

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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