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A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegans

19 Mar 2020

Abstract excerpt

Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we described a physiological program in the nematode Caenorhabditis elegans called the intracellular pathogen response (IPR), which promotes resistance to proteotoxic stress and appears to be distinct from canonical proteostasis pathways. The IPR is controlled by PALS-22 and PALS-25, proteins of unknown biochemical...

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Autophagy in Disease and Therapy
Endoplasmic Reticulum Stress and Disease
Genetics, Aging, and Longevity in Model Organisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32193347
DOI: 10.1073/pnas.1918417117

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