Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of functional hepatocytes by forward programming with nuclear receptors

26 Jul 2022

Abstract excerpt

Production of large quantities of hepatocytes remains a major challenge for a number of clinical applications in the biomedical field. Directed differentiation of human pluripotent stem cells (hPSCs) into hepatocyte-like cells (HLCs) provides an advantageous solution and a number of protocols have been developed for this purpose. However, these methods usually follow different steps of liver development in vitro,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to Pancreatic function and diabetes
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35959725
DOI: 10.7554/elife.71591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of functional hepatocytes by forward programming with nuclear receptorsPMID 35959725Read ↗

Generation of functional hepatocytes by forward programming with nuclear receptorsSemantic proximity Read ↗

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cellsSemantic proximity Read ↗

Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.Semantic proximity Read ↗

A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytesSemantic proximity Read ↗

Thyroid hormone and ALK5 inhibitor improve maturation of human pluripotent stem cell derived hepatocytesSemantic proximity Read ↗

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical researchSemantic proximity Read ↗

A Roadmap for Human Liver Differentiation from Pluripotent Stem CellsSemantic proximity Read ↗

Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytesSemantic proximity Read ↗

Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription FactorSemantic proximity Read ↗

Nuclear factor programming improves stem-cell-derived hepatocyte phenotype.Semantic proximity Read ↗

Effect of Sex Specific differences on Function of Induced Hepatocyte-Like Cells Generated from Male and Female Mouse Embryonic FibroblastsSemantic proximity Read ↗

Generation of integration-free induced hepatocyte-like cells from mouse fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.