Article

Generation of functional hepatocytes by forward programming with nuclear receptors

2022-06-26

Abstract excerpt

Production of large quantities of hepatocytes remains a major challenge for a number of clinical applications in the biomedical field. Directed differentiation of human pluripotent stem cells (hPSC) into hepatocyte-like cells (HLCs) provides an advantageous solution and a number of protocols have been developed for this purpose. However, these methods usually follow different steps of liver development in vitro w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fc32dbf-fab0-5bca-b544-d06814f8550f
DOI: 10.1101/2022.06.23.497371

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation of functional hepatocytes by forward programming with nuclear receptorsDOI 10.1101/2022.06.23.497371Read

Generation of functional hepatocytes by forward programming with nuclear receptorsSemantic proximity Read

Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cellsSemantic proximity Read

Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector.Semantic proximity Read

A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytesSemantic proximity Read

Thyroid hormone and ALK5 inhibitor improve maturation of human pluripotent stem cell derived hepatocytesSemantic proximity Read

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical researchSemantic proximity Read

Leveraging complex interactions between signaling pathways involved in liver development to robustly improve the maturity and yield of pluripotent stem cell-derived hepatocytesSemantic proximity Read

Nuclear factor programming improves stem-cell-derived hepatocyte phenotype.Semantic proximity Read

Effect of Sex Specific differences on Function of Induced Hepatocyte-Like Cells Generated from Male and Female Mouse Embryonic FibroblastsSemantic proximity Read

Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription FactorSemantic proximity Read

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α TransductionSemantic proximity Read

HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cellsSemantic proximity Read