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Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells

18 Jul 2022

Abstract excerpt

BACKGROUND & AIMS: Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLC) have enormous potential as a replacement for primary hepatocytes in drug screening, toxicology and cell replacement therapy, but their genome-wide expression patterns differ strongly from primary human hepatocytes (PHH). METHODS: We differentiated human induced pluripotent stem cells (hiPSC) via definitive endoderm to HLC and...

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PMID: 35863491
DOI: 10.1016/j.jhep.2022.07.009

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