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Article

Synthetic Maturation of Multilineage Human Liver Organoids via Genetically Guided Engineering

2020-05-10

Abstract excerpt

<h4>SUMMARY</h4> Pluripotent stem cell (PSC)-derived organoids are emerging as novel human-based microphysiological models but display immature phenotypes with limited subsets of endothelial or stromal cells. Here we demonstrate that in vitro manipulation of gene regulatory networks (GRNs) in PSC-derived liver organoids selected either through computational analysis or targeted tissue design can advance tissue m...

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Literature Corpus work
1b4b8ed6-81c4-5388-98eb-6ef28ce62435
DOI
10.1101/2020.05.10.087445
Open publication

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Synthetic Maturation of Multilineage Human Liver Organoids via Genetically Guided EngineeringDOI 10.1101/2020.05.10.087445
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