Article

Comparative analysis of uncoupled succinate production by the Fe <sup>II</sup> /2-oxoglutarate-dependent dioxygenases

2024-09-09

Abstract excerpt

Non-heme iron (Fe II ) and 2-oxoglutarate(2OG)-dependent dioxygenases catalyse a diverse array of biological reactions. These enzymes couple the oxidative decarboxylation of 2OG to the hydroxylation of the substrates. However, in the absence of the substrate, oxidative decarboxylation of 2OG generates succinate. We have determined succinate level by using succinyl-CoA synthetase to monitor this uncoupled decarbox...

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Literature Corpus work: e33286b0-ecff-5901-85de-f4f105787e28
DOI: 10.1101/2024.09.09.612061

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