Article

Herpes Simplex Virus-1 targets the 2’-3’cGAMP importer SLC19A1 as an antiviral countermeasure

2024-01-26

Abstract excerpt

<h4>ABSTRACT</h4> To establish a successful infection, herpes simplex virus-1 (HSV-1), a virus with high seropositivity in the human population, must undermine host innate and intrinsic immune defense mechanisms, including the stimulator of interferon genes (STING) pathway. Recently it was discovered that not only de novo produced intracellular 2’-3’cGAMP, but also extracellular 2’-3’cGAMP activates the STING pa...

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Literature Corpus work: 5e3b9023-9fe6-5f59-8420-e00a0afde2d4
DOI: 10.1101/2024.01.24.577105

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