Article

RASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis

2021-01-06

Abstract excerpt

Cell plasticity is a crucial hallmark leading to cancer metastasis. Upregulation of Rho/ROCK pathway drives actomyosin contractility, protrusive forces and contributes to the occurrence of highly invasive amoeboid cells in tumors. Cancer stem cells are similarly associated with metastasis, but how these populations arise in tumors is not fully understood. Here we show that the novel oncogene RASSF1C drives mesench...

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Identifiers and source

Literature Corpus work: 6dc35ab7-07c5-5af2-8c06-9f7347c8cc59
DOI: 10.1101/2021.01.05.425393

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