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Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis

11 Apr 2018

Abstract excerpt

In infants intolerant of enteral feeding because of intestinal disease, parenteral nutrition may be associated with cholestasis, which can progress to end-stage liver disease. Here we show the function of hepatic macrophages and phytosterols in parenteral nutrition-associated cholestasis (PNAC) pathogenesis using a mouse model that recapitulates the human pathophysiology and combines intestinal injury with...

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PMID: 29643332
DOI: 10.1038/s41467-018-03764-1

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