Article

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

2023-09-23

Abstract excerpt

Hepatic factors secreted by the liver promote homeostasis and are pivotal for maintaining the liver-gut axis. Bile acid metabolism is one such example wherein, bile acid synthesis occurs in the liver and its biotransformation happens in the intestine. Dysfunctional interactions between the liver and the intestine stimulate varied pathological outcomes through its bidirectional portal communication. Indeed, aberran...

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Identifiers and source

Literature Corpus work: 787a6c29-71f3-5fa2-820c-e690293fd89f
DOI: 10.1101/2023.09.21.558851

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