Article

One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: relation to chromosomal dosage

2021-12-03

Abstract excerpt

Down syndrome (DS) is the most common chromosomal disorder and it is caused by trisomy of chromosome 21 (Hsa21). Subjects with DS show a large heterogeneity of phenotypes and the most constant clinical features present are typical facies and intellectual disability (ID). Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all one-carbon cycle. We performed en...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2c5902a-057d-53ca-a72b-e3e0136b00e1
DOI: 10.1101/2021.11.30.470411

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: relation to chromosomal dosageDOI 10.1101/2021.11.30.470411Read

One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome.Semantic proximity Read

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolismSemantic proximity Read

Red blood cell metabolism in Down syndrome: hints on metabolic derangements in agingSemantic proximity Read

Plasma metabolome and cognitive skills in Down syndromeSemantic proximity Read

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptorsSemantic proximity Read

Altered Hepatic Metabolism in Down SyndromeSemantic proximity Read

One-Carbon Metabolism–Genome Interactions in Folate-Associated Pathologies ,Semantic proximity Read

Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndromeSemantic proximity Read

Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome?Semantic proximity Read

Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.Semantic proximity Read

Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and Down syndrome?Semantic proximity Read

The transcriptome profile of human trisomy 21 blood cellsSemantic proximity Read