Article

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

2018-08-29

Abstract excerpt

<h4>ABSTRACT</h4> Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by unknown mechanisms. We report here the results of a large metabolomics study showing that people with DS produce elevated levels of kynurenine and quinolinic acid, two tryptophan catabolites with potent immunosuppressive and neurotoxic properties, respectively. We found that immune cells of people with DS o...

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Literature Corpus work: e280a38e-86f8-5ded-ba38-ac179110b604
DOI: 10.1101/403642

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