The transcriptome profile of human trisomy 21 blood cells

doi:10.1186/s40246-021-00325-4

Article

The transcriptome profile of human trisomy 21 blood cells

1 May 2021

Abstract excerpt

BACKGROUND: Trisomy 21 (T21) is a genetic alteration characterised by the presence of an extra full or partial human chromosome 21 (Hsa21) leading to Down syndrome (DS), the most common form of intellectual disability (ID). It is broadly agreed that the presence of extra genetic material in T21 gives origin to an altered expression of genes located on Hsa21 leading to DS phenotype. The aim of this study was to...

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