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Article

One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome.

Human cell - 1 Nov 2021

Mendes Cristiani Cortez, Zampieri Bruna Lancia, Arantes Lidia Maria Rebolho Batista, Melendez Matias Eliseo, Biselli Joice Matos, Carvalho André Lopes, Eberlin Marcos Nogueira, Riccio Maria Francesca, Vannucchi Hélio, Carvalho Valdemir Melechco, Goloni-Bertollo Eny Maria, Pavarino Érika Cristina

Abstract excerpt

Down syndrome (DS) is the most common chromosomal disorder, resulting from the failure of normal chromosome 21 segregation. Studies have suggested that impairments within the one-carbon metabolic pathway can be of relevance for the global genome instability observed in mothers of individuals with DS. Based on the association between global DNA hypomethylation, genome instability, and impairments within the...

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PMID: 34410622
DOI: 10.1007/s13577-021-00586-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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