Article
Coxiella burnetii Employs the Dot/Icm Type IV Secretion System to Modulate Host NF-κB/RelA Activation.
Frontiers in cellular and infection microbiology - 1 Jan 2016
Mahapatra Saugata, Gallaher Brandi, Smith Sydni Caet, Graham Joseph G, Voth Daniel E, Shaw Edward I
Abstract excerpt
Coxiella burnetii is the causative agent of Q fever and an obligate intracellular pathogen in nature that survives and grows in a parasitophorous vacuole (PV) within eukaryotic host cells. C. burnetii promotes intracellular survival by subverting apoptotic and pro-inflammatory signaling pathways that are typically regulated by nuclear transcription factor-κB (NF-κB). We and others have demonstrated that C....
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