Back to search

Article

A recombinant selective drug-resistant <i>M. bovis</i> BCG enhances the bactericidal activity of a second-line tuberculosis regimen

2021-03-05

Abstract excerpt

Drug-resistant tuberculosis (DR-TB) results from infection by Mycobacterium tuberculosis strains resistant to at least rifampin or isoniazid. To improve the treatment outcome in DR-TB, therapeutic vaccines are considered an ideal choice as they can enhance pathogen clearance and minimize disease sequelae. To date, there is no therapeutic vaccine reported to be effective when combined with a chemotherapy regimen a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e2ae99f5-0279-59b8-a3a4-22e205c12f5e
DOI
10.1101/2021.03.04.434024
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A recombinant selective drug-resistant <i>M. bovis</i> BCG enhances the bactericidal activity of a second-line tuberculosis regimenDOI 10.1101/2021.03.04.434024
Recombinant BCG to Enhance Its Immunomodulatory ActivitiesSemantic proximity
Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memorySemantic proximity
Therapeutic DNA Vaccine Targeting <i>Mycobacterium tuberculosis</i> Persisters Shortens Curative Tuberculosis TreatmentSemantic proximity
Manipulation of BCG vaccine: a double-edged swordSemantic proximity
Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines <i>Mycobacterium bovis</i> BCG and <i>Mycobacterium microti</i>Semantic proximity
Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency.Semantic proximity
Attenuated <i>Mycobacterium tuberculosis</i> Vaccine Protection in a Low Dose Murine Challenge ModelSemantic proximity
BCG VaccinesSemantic proximity
Crucial requirement for standardization during the development of novel recombinant BCG vaccines: Does the corresponding substrain background matter?Semantic proximity
Deletion of RD1 from<i>Mycobacterium tuberculosis</i>Mimics Bacille Calmette‐Guérin AttenuationSemantic proximity
Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis.Semantic proximity
Development of an Engineered <i>Mycobacterium tuberculosis</i> Strain for a Safe and Effective Tuberculosis Human Challenge ModelSemantic proximity
Select a neighboring publication to make it the new centre.