Article
Crucial requirement for standardization during the development of novel recombinant BCG vaccines: Does the corresponding substrain background matter?
Human vaccines & immunotherapeutics - 1 Dec 2016
Antas P R Z
Abstract excerpt
The Bacillus Calmette-Guerin (BCG) vaccine is not a single organism, but consists of substrains that vary in genotypes and phenotypes. Actually, BCG is the common name given to a family of vaccines created in 1921 by the in vitro attenuation of a virulent Mycobacterium bovis in France. Even nearly a century of use, the BCG vaccine lingers generating confusion and debate due to its diversity and failure to protect...
Topics
- BCG Vaccine
- Drug Evaluation
- Genetic Variation
- Humans
- Mycobacterium bovis
- Vaccination