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Development of an Engineered <i>Mycobacterium tuberculosis</i> Strain for a Safe and Effective Tuberculosis Human Challenge Model

2023-11-19

Abstract excerpt

Human challenge experiments could greatly accelerate the development of a tuberculosis (TB) vaccine. Human challenge for tuberculosis requires a strain that can both replicate in the host and be reliably cleared. To accomplish this, we designed Mycobacterium tuberculosis (Mtb) strains featuring up to three orthogonal kill switches, tightly regulated by exogenous tetracyclines and trimethoprim. The resultant strai...

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Identifiers and source

Literature Corpus work
56905e4e-09ad-5a95-b8e0-5c86708d759f
DOI
10.1101/2023.11.19.567569
Open publication

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Development of an Engineered <i>Mycobacterium tuberculosis</i> Strain for a Safe and Effective Tuberculosis Human Challenge ModelDOI 10.1101/2023.11.19.567569
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