Article

Transcriptional activity generates chromatin motion that drives nuclear blebbing

2025-05-21

Abstract excerpt

Abnormal nuclear morphology is a hallmark of human diseases, including cancers and age-related disorders. Previously, maintenance of nuclear morphology and integrity was thought to be solely dependent on a force balance between nuclear mechanical resistance and actin antagonism. However, our recent work revealed that inhibiting RNA polymerase II suppresses nuclear blebbing independent of altering force balance, bu...

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Literature Corpus work: e2a43c69-cd6f-5d68-a96b-1dbf8b7cf59c
DOI: 10.1101/2025.05.20.655131

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