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Article

Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy.

Investigative ophthalmology & visual science - 15 Mar 2013

Matthaei Mario, Hu Jianfei, Meng Huan, Lackner Eva-Maria, Eberhart Charles G, Qian Jiang, Hao Haiping, Jun Albert S

Abstract excerpt

PURPOSE: To investigate the endothelial gene expression profile in a Col8a2 Q455K mutant knock-in mouse model of early-onset Fuchs' endothelial corneal dystrophy (FECD) and identify potential targets that can be correlated to human late-onset FECD. METHODS: Diseased or normal endothelial phenotypes were verified in 12-month-old homozygous Col8a2(Q455K/Q455K) mutant and wild-type mice by clinical confocal...

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Identifiers

PMID: 23449721
DOI: 10.1167/iovs.12-10898
PMCID: PMC3604908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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