Article

<i>TCF4</i> trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy

2022-06-28

Abstract excerpt

<h4>ABSTRACT</h4> Fuchs endothelial corneal dystrophy (FECD), the leading indication for corneal transplantation in the U.S., causes loss of corneal endothelial cells (CECs) and corneal edema leading to vision loss. FECD pathogenesis is linked to impaired response to oxidative stress and environmental ultraviolet A (UVA) exposure. Although UVA is known to cause nonapoptotic oxidative cell death resulting from iro...

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Literature Corpus work: 721f6a5f-13f8-59dd-8aaa-3108ba8e755b
DOI: 10.1101/2022.06.27.497862

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