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Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.

Investigative ophthalmology & visual science - 5 Jan 2026

Zhao Xintian, Duan Haoyun, Dou Shengqian, Li Xiaoyu, Lin Yujing, Zhao Can, Li Dongfang, Zhou Libo, Li Zongyi, Zhou Qingjun

Abstract excerpt

Purpose: The purpose of this study was to characterize the early transcriptomic and pathologic changes of Fuchs endothelial corneal dystrophy (FECD) using the Col8a2Q455K/Q455K mutant mouse model. Methods: The Col8a2Q455K/Q455K mutant mice were divided into the early-stage (≤2-month-old) group and the late-stage (≥8-month-old) group, based on corneal endothelial changes evaluated by slit-lamp microscopy, optical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41575439
DOI: 10.1167/iovs.67.1.53
PMCID: PMC12854232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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