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Article

L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy.

Investigative ophthalmology & visual science - 28 Mar 2013

Meng Huan, Matthaei Mario, Ramanan Narendrakumar, Grebe Rhonda, Chakravarti Shukti, Speck Caroline L, Kimos Martha, Vij Neeraj, Eberhart Charles G, Jun Albert S

Abstract excerpt

PURPOSE: We compared the cellular phenotypes and studied the role of autophagy in the pathogenesis of Fuchs endothelial corneal dystrophy (FECD) using two α2 collagen VIII (Col8a2) knock-in mouse models and human FECD tissues. METHODS: In vivo corneal endothelial cell (CEC) counts and morphology were analyzed by clinical confocal microscopy. Ultrastructural analysis of CECs was performed by transmission electron...

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Identifiers

PMID: 23422828
DOI: 10.1167/iovs.12-11021
PMCID: PMC3626522

Genes

DRAM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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