Article

Characterization of a novel mouse model for Fuchs Endothelial Corneal Dystrophy

2023-10-06

Abstract excerpt

<h4>Purpose</h4> Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive blinding disorder prevalent in 4% of Americans over 40. Corneal transplantation is the standard treatment. Animal models with partial FECD features exist, but a model encompassing all the major disease characteristics is desirable to improve the understanding of the pathogenesis and to identify signaling pathways involved in the disease...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70716bbc-252f-5dfd-a6a8-6ce60d46a985
DOI: 10.1101/2023.10.06.561253

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of a novel mouse model for Fuchs Endothelial Corneal DystrophyDOI 10.1101/2023.10.06.561253Read

Preclinical Models for Studying Fuchs Endothelial Corneal DystrophySemantic proximity Read

Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.Semantic proximity Read

L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy.Semantic proximity Read

Interplay between ferroptosis and guttae in an early-onset murine model of Fuchs’ endothelial corneal dystrophy (FECD)Semantic proximity Read

An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis.Semantic proximity Read

Fuchs endothelial corneal dystrophy: current perspectivesSemantic proximity Read

Fuchs endothelial corneal dystrophy: current perspectives on diagnostic pathology and genetics—Bowman Club LectureSemantic proximity Read

Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy.Semantic proximity Read

TAZ ( <i>Wwtr1</i> ) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs’ endothelial corneal dystrophySemantic proximity Read

Genetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophySemantic proximity Read

Fuchs Corneal Dystrophy.Semantic proximity Read

Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene.Semantic proximity Read