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Article

GLP-1R R131Q links long-range conformational remodeling to cellular stress phenotypes.

Journal of molecular graphics & modelling - 1 Jul 2026

Kato Takashi, Inomata Noriko, Serizawa Keiko, Matsuo Yoshinori, Oguchi Misato, Kuranami Satoshi, Sakurai Yoshitaka, Aoyama Tomohisa, Suzuki Ken, Shojima Nobuhiro, Yamauchi Toshimasa

Abstract excerpt

Glucagon-like peptide-1 receptor (GLP-1R) agonists show substantial inter-individual variability in efficacy, but the structural basis by which common GLP-1R variants alter receptor behavior remains unclear. We examined the GLP-1R R131Q variant using all-atom molecular dynamics simulations across four conditions (wild type [WT] and R131Q in ligand-free and GLP-1-bound states; 8-11 replicas per condition; 600 ns...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42167066
DOI: 10.1016/j.jmgm.2026.109445

Genes

IDH2
MDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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