Back to search

Article

The renal response to FGF23 shifts from phosphaturia towards inflammation in kidney disease

2025-03-05

Abstract excerpt

<h4>Background</h4> FGF23 excess is associated with morbidity and mortality, but the role of excessive circulating FGF23 concentrations as a mere biomarker or causative factor of pathology is controversial. Here, we investigated the consequences of FGF23 excess in kidney disease. <h4>Methods</h4> This study used three independent disease models: i) anti-glomerular basement membrane (Anti-GBM) disease in male C57...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b4bfd2dc-6fd0-54c3-ae41-34bedd575a37
DOI
10.1101/2025.03.01.640954
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The renal response to FGF23 shifts from phosphaturia towards inflammation in kidney diseaseDOI 10.1101/2025.03.01.640954
Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory TargetsSemantic proximity
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progressionSemantic proximity
An integrated organoid omics map extends modeling potential of kidney diseaseSemantic proximity
An integrated organoid omics map extends modeling potential of kidney diseaseSemantic proximity
Multidimensional Data Integration Identifies Tumor Necrosis Factor Activation in Nephrotic Syndrome: A Model for Precision NephrologySemantic proximity
Chronically elevated FGF23 drives sustained renal ERK signaling and inflammatory transcriptional programs mitigated by cFGF23 gene therapySemantic proximity
Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progressionSemantic proximity
Multi-Omics and Experimental Validation Reveal the Targets and Mechanisms of Urolithin A in diabetic kidney diseaseSemantic proximity
The immune cell landscape in kidneys of lupus nephritis patientsSemantic proximity
Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progressionSemantic proximity
Hypoxic injury triggers maladaptive repair in human kidney organoidsSemantic proximity
Integrin αM promotes macrophage alternative M2 polarization in hyperuricemia-related chronic kidney diseaseSemantic proximity
Select a neighboring publication to make it the new centre.