Article

AAV-mediated Klotho gene delivery attenuates renal fibrosis in chronic kidney disease by suppressing the TGF-β/Smad3 signaling pathway

2026-07-08

Abstract excerpt

<title>Abstract</title> <p>Background: Chronic kidney disease (CKD) is characterised by progressive renal fibrosis, Klotho deficiency, and dysregulated transforming growth factor-beta 1/Smad3 signalling. Adeno-associated virus gene therapy may sustainably restore renal Klotho. <h4>Objectives:</h4> To determine whether AAV9-mediated Klotho delivery via renal vein injection attenuates CKD fibrosis by suppressing TG...

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Literature Corpus work: aac2ca94-7f8e-5f6c-a048-758d6241f05f
DOI: 10.21203/rs.3.rs-9670512/v1

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