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Article

Aldehyde dehydrogenase 2 deficiency significantly exacerbates tert-butyl alcohol-induced toxicity in mice.

Journal of applied toxicology : JAT - 1 Jul 2020

Lin Liping, Suda Megumi, Xu Chenlan, Zhang Yuehan, Yanagiba Yukie, Nie Jisheng, Nakajima Tamie, Weng Zuquan, Wang Rui-Sheng

Abstract excerpt

Owing to the use of ethyl tert-butyl ether (ETBE) as a fuel additive, the possible adverse effects of ETBE exposure have become a public concern. Our previous study showed that ETBE-induced toxicity in aldehyde dehydrogenase 2 (Aldh2) gene knockout (KO) mice was caused by its primary metabolite acetaldehyde, which was toxic. However, it is unclear whether tert-butyl alcohol (TBA), another main metabolite of ETBE,...

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Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32059264
DOI: 10.1002/jat.3957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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