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Article

Molecular Basis of Alcohol-Related Gastric and Colon Cancer

24 May 2017

Abstract excerpt

Many meta-analysis, large cohort studies, and experimental studies suggest that chronic alcohol consumption increases the risk of gastric and colon cancer. Ethanol is metabolized by alcohol dehydrogenases (ADH), catalase or cytochrome P450 2E1 (CYP2E1) to acetaldehyde, which is then further oxidized to acetate by aldehyde dehydrogenase (ALDH). Acetaldehyde has been classified by the International Agency for...

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PMID: 28538665
DOI: 10.3390/ijms18061116

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