Article

A novel regulatory loop FBXW7/MAP4 promotes esophageal squamous cell carcinoma progression via ERK phosphorylation

2022-07-05

Abstract excerpt

<h4>Background: </h4> Increasing evidence suggests that FBXW7 has a high frequency of mutations in esophageal squamous cell carcinoma (ESCC). However, the function of FBXW7, especially the mutations, is not clear. This study was designed to investigate the functional significance of FBXW7 loss of function and underlying mechanism in ESCC. <h4>Methods:</h4> Immunofluorescence was applied to clarify the localization...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e2610568-3d06-55d6-92db-837d6c5484f4
DOI: 10.21203/rs.3.rs-1782721/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel regulatory loop FBXW7/MAP4 promotes esophageal squamous cell carcinoma progression via ERK phosphorylationDOI 10.21203/rs.3.rs-1782721/v1Read

FBXW7 as a potential prognostic biomarker for ESCC inhibits the progression of ESCC by directly inhibiting the stemness of tumor cellsSemantic proximity Read

Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinomaSemantic proximity Read

FBXW7 inhibits the Progression of ESCC by directly inhibiting the Stemness of Tumor CellsSemantic proximity Read

Tumor suppressor functions of FBW7 in cancer development and progressionSemantic proximity Read

FBXW7: a critical tumor suppressor of human cancers.Semantic proximity Read

Clinical significance of FBXW7 loss of function in human cancersSemantic proximity Read

Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligaseSemantic proximity Read

Recent insight into the role of FBXW7 as a tumor suppressor.Semantic proximity Read

Comprehensive Study of Human FBXW7 Deleterious nsSNP's Functional Inference and Susceptibility to Gynaecological CancerSemantic proximity Read

Loss of FBXW7 is related to the susceptibility and poor prognosis of cervical squamous carcinoma.Semantic proximity Read

ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.Semantic proximity Read

FBXW7 in breast cancer: mechanism of action and therapeutic potentialSemantic proximity Read