Article
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer.
Cell research - 1 May 2015
Ji Shunrong, Qin Yi, Shi Si, Liu Xiangyuan, Hu Hongli, Zhou Hu, Gao Jing, Zhang Bo, Xu Wenyan, Liu Jiang, Liang Dingkong, Liu Liang, Liu Chen, Long Jiang, Zhou Haijun, Chiao Paul J, Xu Jin, Ni Quanxing, Gao Daming, Yu Xianjun
Abstract excerpt
F-box and WD repeat domain-containing 7 (FBW7) is the substrate recognition component of the Skp1-Cul1-F-box (SCF) ubiquitin ligase complex and functions as a major tumor suppressor by targeting various oncoproteins for degradation. Genomic deletion or mutation of FBW7 has frequently been identified in many human cancers but not in pancreatic ductal adenocarcinoma. Thus it is important to know how the tumor...
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