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Article

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis.

Nature chemical biology - 1 Nov 2014

Kariolis Mihalis S, Miao Yu Rebecca, Jones Douglas S, Kapur Shiven, Mathews Irimpan I, Giaccia Amato J, Cochran Jennifer R

Abstract excerpt

Aberrant signaling through the Axl receptor tyrosine kinase has been associated with a myriad of human diseases, most notably metastatic cancer, identifying Axl and its ligand Gas6 as important therapeutic targets. Using rational and combinatorial approaches, we engineered an Axl 'decoy receptor'...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25242553
DOI: 10.1038/nchembio.1636
PMCID: PMC4372605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25242553-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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