Article

Elevated plasma cholesterol causally improves sepsis outcome by promoting hepatic metabolic reprogramming

2025-10-27

Abstract excerpt

<h4>Rationale</h4> Sepsis is a life-threatening condition with high mortality and limited therapeutic options. While hypocholesterolemia is associated with poor outcomes, the causal role of cholesterol and its underlying mechanisms remain unclear. <h4>Objectives</h4> To determine whether elevated plasma cholesterol improves sepsis survival and to elucidate the mechanistic basis of this effect. <h4>Methods</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e235565d-99f0-5ed8-91a4-8edd663cdab1
DOI: 10.1101/2025.10.22.683940

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elevated plasma cholesterol causally improves sepsis outcome by promoting hepatic metabolic reprogrammingDOI 10.1101/2025.10.22.683940Read

The Impact of Statin Use on Sepsis MortalitySemantic proximity Read

Identification and Validation of a Lipid Metabolism-associated Gene Signature for Predicting Survival in Sepsis PatientsSemantic proximity Read

Metabolic Biomarkers and Endotypes as Predictors of Sepsis Outcomes: A Prospective Population-Based Cohort Analysis from the UK BiobankSemantic proximity Read

Metabolic phenotyping of sepsis in large multicenter cohorts: identification of a reproducible high-risk subgroup.Semantic proximity Read

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?Semantic proximity Read

Epigenetic and metabolic programming of innate immunity in sepsisSemantic proximity Read

Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality.Semantic proximity Read

Genetic correlations and causal relationships between cardio-metabolic traits and sepsis.Semantic proximity Read

Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis.Semantic proximity Read

Genetic association of lipids and lipid-lowering drugs with sepsis: a Mendelian randomization and mediation analysisSemantic proximity Read

A comprehensive understanding of HDL-associated apolipoproteins: future potential biomarker in sepsis.Semantic proximity Read

Genetic insights into cholesteryl ester transfer protein as a novel therapeutic target for sepsis and severe pneumoniaSemantic proximity Read