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Article

Metabolic phenotyping of sepsis in large multicenter cohorts: identification of a reproducible high-risk subgroup.

Lipids in health and disease - 5 Feb 2026

Zhang Yining, Liu Guoxiang, Shang Zhaoming, Yu Xianxian, Shang Huailong, Cui Xiao, Chen Jiameng, Ye Jiawei, Zhang Jiyuan, Zhai Yidan, Qian Junwei, Ma Chaoping, Liu Wenjie, Chen Mingquan, Zhao Bing, Gao Chengjin

Abstract excerpt

BACKGROUND: Sepsis represents a profound metabolic crisis, yet the prognostic significance of glycolipid biomarkers remains unclear. Most prior studies examined single metabolic indicators, overlooking their combined effects on organ dysfunction and survival. This study aimed to identify glycolipid-related biomarkers predicting outcomes in sepsis and to define a reproducible metabolic phenotype linked to...

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Identifiers

PMID: 41645160
DOI: 10.1186/s12944-026-02888-4
PMCID: PMC12918294

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