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Article

Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality.

Critical care (London, England) - 24 Dec 2024

Augustin Beulah, Wu Dongyuan, Black Lauren Page, Bertrand Andrew, Sulaiman Dawoud, Hopson Charlotte, Jacob Vinitha, Shavit Jordan A, Hofmaenner Daniel A, Labilloy Guillaume, Smith Leslie, Cagmat Emilio, Graim Kiley, Datta Susmita, Reddy Srinivasa T, Guirgis Faheem W

Abstract excerpt

BACKGROUND: Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis. METHODS: Data from four adult sepsis studies were analyzed and findings were investigated in two external datasets. Previously characterized lipid dysregulation subphenotypes of hypolipoprotein (HYPO; low lipoproteins, increased mortality) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39716214
DOI: 10.1186/s13054-024-05216-3
PMCID: PMC11667828

Genes

DHCR7
LDLR
ALOX5
MSMO1
PCSK9
PLTP
FDFT1

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