Article

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition

2024-11-15

Abstract excerpt

Poly(ADP-ribose) polymerase1 (PARP1) plays a vital role in DNA repair and its inhibition in cancer cells may cause cell apoptosis. In this study, we investigated the effects of a PARP1 variant, V762A, which is strongly associated with several cancers in humans, on the inhibition of PARP1 by three FDA approved inhibitors: niraparib, rucaparib and talazoparib. Our work suggests that these inhibitors bind to the V762...

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Identifiers and source

Literature Corpus work: 22d95329-e1ff-58b6-85ae-a1d89ad7e969
DOI: 10.1101/2024.11.13.623412

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