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Article

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition.

The journal of physical chemistry. B - 27 Feb 2025

Shanmugam Neel, Chatterjee Shubham, Cisneros G Andrés

Abstract excerpt

Poly(ADP-ribose) polymerase1 (PARP1) plays a vital role in DNA repair, and its inhibition in cancer cells may cause cell apoptosis. In this study, we investigated the effects of a PARP1 variant, V762A, which is strongly associated with several cancers in humans, on the inhibition of PARP1 by three FDA-approved inhibitors: niraparib, rucaparib, and talazoparib. Specifically, we compared the inhibition of the...

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Identifiers

PMID: 39962867
DOI: 10.1021/acs.jpcb.4c07960
PMCID: PMC12005076

Genes

PARP1

Variants

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Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition.PMID 39962867Read ↗

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