Article

A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation

2024-05-20

Abstract excerpt

<h4>Summary</h4> PARP1 and PARP2 recognize DNA breaks immediately upon their formation, generate a burst of local PARylation to signal their location, and are co-targeted by all current FDA-approved forms of PARP inhibitors (PARPi) used in the cancer clinic. Recent evidence indicates that the same PARPi molecules impact PARP2 differently from PARP1, raising the possibility that allosteric activation may also diff...

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Literature Corpus work: 8b8bdc2b-a0ac-5ba8-b443-a0fcd1723f7c
DOI: 10.1101/2024.05.20.594972

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