Article

Recent Progress in Poly(ADP–Ribose) Polymerase‐1 Inhibitors for Application in Cancer

2025-01-01

Abstract excerpt

Abstract An ADP‐ribosylating enzyme called poly (ADP–ribose) polymerase 1 (PARP1) is necessary to start several types of DNA repair. PARP1 also contributes significantly to the regulation of gene expression through enzyme‐independent motif recognition and enzyme‐dependent chromatin remodeling. Thus, synthetic lethality is achieved in the therapy of tumors and cancers by blocking undesired DNA repair by the inhibit...

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Literature Corpus work: 99c46620-888d-5b03-93d4-ed40f00b0b50
DOI: 10.1002/slct.202404277

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